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Immunoscintigraphy of endometriosis
S H Kennedy1, O A Mojiminiyi, N D Soper
1Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford.
British Journal of Obstetrics and Gynaecology
|August 1, 1990
Summary
Immunoscintigraphy using radiolabeled OC-125 F(ab)2 fragments showed potential for diagnosing endometriosis. This imaging technique achieved 89% sensitivity for endometriosis and 91% for benign pelvic disease.
Area of Science:
- Gynecology
- Nuclear Medicine
- Immunodiagnostics
Background:
- Endometriosis diagnosis remains challenging, often requiring invasive surgical procedures.
- Accurate preoperative identification of pelvic endometriosis is crucial for effective surgical planning and treatment.
Purpose of the Study:
- To evaluate the efficacy of immunoscintigraphy with radiolabeled monoclonal antibody OC-125 F(ab)2 fragments in detecting pelvic endometriosis.
- To determine the sensitivity and specificity of this imaging modality for diagnosing endometriosis and other benign pelvic diseases.
Main Methods:
- Twenty-eight women with suspected endometriosis or infertility underwent pre-operative immunoscintigraphy.
- Radiolabeled monoclonal antibody OC-125 F(ab)2 fragments were administered intravenously.
- Results were correlated with surgical findings.
Main Results:
- Immunoscintigraphy was positive in 22 women and negative in five.
- The method demonstrated 89% sensitivity and 33% specificity for endometriosis diagnosis.
- For benign pelvic disease, sensitivity was 91% and specificity was 60%.
Conclusions:
- Immunoscintigraphy with OC-125 F(ab)2 fragments shows promise as a non-invasive tool for detecting pelvic endometriosis.
- The technique offers high sensitivity for both endometriosis and broader benign pelvic pathology.
- Further research is warranted to improve specificity and clinical integration.