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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

Intracranial atherosclerosis

Adnan I Qureshi1, Louis R Caplan2

  • 1Zeenat Qureshi Stroke Institute and CentraCare Health, St Cloud, MN, USA.

Lancet (London, England)
|September 7, 2013
PubMed

Insights

Intracranial atherosclerosis, a condition affecting brain arteries, is linked to age, hypertension, and diabetes. Early diagnosis and treatment, including medications and procedures, are crucial to prevent recurrent ischemic strokes.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Vascular Surgery

Background:

  • Atherosclerotic disease commonly affects intracranial arteries, both within and outside the cranial bones.
  • Key risk factors for intracranial atherosclerosis include advanced age, hypertension, and diabetes mellitus.
  • This condition can lead to thromboembolism and/or hypoperfusion, causing transient or permanent cerebral ischemic events.

Purpose of the Study:

  • To highlight the significance of intracranial atherosclerosis.
  • To emphasize the need for early diagnosis and prompt treatment of intracranial atherosclerosis.
  • To outline current therapeutic strategies for managing intracranial atherosclerosis.

Main Methods:

  • Review of existing literature on intracranial atherosclerosis.
  • Analysis of risk factors associated with the condition.
  • Summary of current treatment modalities.

Main Results:

  • Intracranial atherosclerosis is associated with significant risk factors like age, hypertension, and diabetes.
  • The condition poses a high risk for recurrent ischemic stroke and other cardiovascular events.
  • Current treatments involve antiplatelet drugs, blood pressure and cholesterol management, and revascularization procedures.

Conclusions:

  • Intracranial atherosclerosis requires early detection and management due to high recurrence rates.
  • A multi-faceted treatment approach is necessary for effective patient outcomes.
  • Further research may refine treatment protocols for intracranial atherosclerosis.

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