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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

[Risk factors for recurrent upper airways infections in pre-school children]

Alexander Ciria-Martin1, Frank Caravia-Bernardo, Mirta Álvarez-Castelló

  • 1Hospital Pedi·trico Universitario William Soler, calle San Francisco, esquina Perla, Altahabana, Boyeros, Cuba.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|September 7, 2013
PubMed

Insights

Recurrent upper respiratory infections in preschoolers are linked to allergies like house dust mite sensitization and high IgE levels. Exclusive breastfeeding and adequate weaning can protect children from these infections.

Area of Science:

  • Pediatrics
  • Immunology
  • Allergy

Background:

  • Upper respiratory infections (URIs) are a significant cause of illness in preschool children.
  • Frequent URIs can indicate an underlying atopic condition.

Purpose of the Study:

  • To identify risk factors associated with recurrent URIs in preschool children.
  • To explore the role of allergic manifestations in recurrent URIs.

Main Methods:

  • A longitudinal study design involving patients and controls.
  • Data collection included environmental factor inquiries, nasopharyngeal cultures, allergy skin tests, and serum immunoglobulin measurements.

Main Results:

  • Pharyngo-tonsillitis and adenoiditis were the most common URIs.
  • Key risk factors identified were house dust mite sensitization (OR:106), high IgE levels (OR:27.7), atopy (OR:10.5), parental smoking (OR:4.8), and low IgG/IgA (OR:14/8.7).
  • Exclusive breastfeeding and adequate weaning demonstrated protective effects.

Conclusions:

  • Allergic hypersensitivity, particularly house dust mite sensitization and elevated IgE, are major risk factors for recurrent URIs in preschoolers.
  • Environmental modifications to reduce allergen exposure and promotion of breastfeeding/weaning are recommended to decrease URI incidence.
Abstract

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