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Modulation of neoplastic development: concepts and examples.

M Roberfroid1, V Préat

  • 1Unité de biochimie toxicologique et cancérologique, Université catholique de Louvain, Bruxelles, Belgique.

Bulletin Du Cancer
|January 1, 1990
PubMed
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Neoplastic development can be modulated, either accelerated or slowed, by various agents after initial chemical carcinogenesis. This modulation concept expands beyond traditional promotion phases in cancer development.

Area of Science:

  • Oncology
  • Toxicology
  • Molecular Biology

Background:

  • Chemical carcinogenesis is a multiphasic process involving initiation, promotion, and progression.
  • Traditional models focus on distinct, sequential phases of cancer development.
  • The role of external factors in altering established carcinogenic pathways requires further definition.

Purpose of the Study:

  • To introduce and define the concept of "modulation" in neoplastic development.
  • To differentiate modulation from the established phase of promotion in carcinogenesis.
  • To explore the diverse agents and mechanisms involved in modulating carcinogenic processes.

Main Methods:

  • Conceptual framework development for neoplastic development modulation.
  • Review of existing literature on chemical carcinogenesis and related factors.

Related Experiment Videos

  • Analysis of how various agents influence preneoplastic lesions and cancer appearance.

    • Main Results:

    • Modulation encompasses treatments that accelerate or decelerate carcinogenesis post-initiation.
    • Modulation is not synonymous with promotion, as it's not an obligatory phase.
    • Agents like chemical carcinogens, xenobiotics, endogenous factors, and infections can modulate liver carcinogenesis.
    • Effects on preneoplastic lesions may differ quantitatively and qualitatively from effects on cancer incidence.
    • Modulation may involve metabolic perturbations and cell proliferation.

    Conclusions:

    • The concept of modulation offers a broader perspective on factors influencing cancer progression.
    • Understanding modulation is crucial for developing targeted strategies against chemical carcinogenesis.
    • Further research is needed to elucidate the precise mechanisms of modulating agents.