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From molecules to mastication: the development and evolution of teeth
Andrew H Jheon1, Kerstin Seidel, Brian Biehs
1Department of Orofacial Sciences and Program in Craniofacial and Mesenchymal Biology, University of California San Francisco, San Francisco, CA, USA.
Wiley Interdisciplinary Reviews. Developmental Biology
|September 7, 2013
Summary
This review explores tooth development and evolution in vertebrates. It covers key research areas like morphogenesis, genetics, evolutionary pathways, and dental stem cells for regenerative medicine.
Area of Science:
- Developmental Biology
- Evolutionary Biology
- Regenerative Medicine
Background:
- Teeth are unique vertebrate structures crucial for evolution.
- Tooth development serves as a model for organogenesis research.
- Fossilized teeth are vital for paleontology and anthropology.
Purpose of the Study:
- To review major research areas in tooth development and evolution.
- To highlight the significance of teeth in evolutionary biology.
- To discuss the potential of dental stem cells in regenerative medicine.
Main Methods:
- Review of existing literature on tooth development and evolution.
- Analysis of molecular pathways and morphogenetic processes.
- Examination of genetic and signaling mechanisms in tooth formation.
Main Results:
- Epithelial/mesenchymal interactions are key to tooth organogenesis.
- Dental stem cells offer promise for regenerative medicine.
- Teeth provide insights into vertebrate evolution and development.
Conclusions:
- Tooth development is a complex process involving intricate molecular signaling.
- The study of teeth bridges developmental biology, evolutionary science, and regenerative medicine.
- Further research into dental stem cells could revolutionize restorative therapies.
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