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Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: May 8, 2026

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
08:07

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Published on: May 19, 2020

Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression.

Renukaradhya J Gourapura1, Masood A Khan, Richard M Gallo

  • 1Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Plos One
|September 7, 2013
PubMed
Summary
This summary is machine-generated.

Major Histocompatibility Complex class I (MHC class I) molecules regulate CD1d function by physically associating with CD1d. This association masks CD1d, impacting lipid antigen presentation to Natural Killer T (NKT) cells.

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Last Updated: May 8, 2026

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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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Published on: April 18, 2016

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • CD1d molecules are structurally similar to MHC class I but present lipid antigens.
  • MHC class I molecules typically present peptide antigens.

Purpose of the Study:

  • To investigate the physical association between MHC class I and CD1d molecules.
  • To determine the functional consequences of this association on CD1d-mediated antigen presentation to NKT cells.

Main Methods:

  • Acid stripping of MHC class I molecules from antigen-presenting cells.
  • Analysis of surface expression of murine CD1d.
  • Assessment of CD1d-mediated antigen presentation to NKT cells.
  • Comparison of NKT cell populations and CD1d antigen presentation in TAP1-/- mice versus wild-type mice.

Main Results:

  • MHC class I molecules physically associate with and regulate the surface expression of mouse CD1d.
  • Low pH acid stripping of MHC class I increased surface CD1d expression and augmented CD1d-mediated antigen presentation to NKT cells.
  • TAP1-/- mice exhibited a higher percentage of type I NKT cells and enhanced CD1d antigen presentation by dendritic cells.

Conclusions:

  • MHC class I molecules regulate NKT cell function by masking CD1d.
  • This interaction influences the availability of CD1d for lipid antigen presentation.