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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Targeting cellular antioxidant enzymes for treating atherosclerotic vascular disease

Dong Hoon Kang1, Sang Won Kang

  • 1Division of Life and Pharmaceutical Science and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120-750, Republic of Korea.

Biomolecules & Therapeutics
|September 7, 2013
PubMed

Insights

Atherosclerotic vascular dysfunction involves oxidative stress, but general antioxidant vitamins are ineffective. Targeting specific antioxidant enzymes or developing enzyme-mimetics may offer a therapeutic strategy for this inflammatory disease.

Area of Science:

  • Biomedical Science
  • Cardiovascular Research
  • Oxidative Stress Biology

Background:

  • Atherosclerotic vascular dysfunction is a chronic inflammatory process.
  • Reactive oxygen species (ROS) are key players in atherosclerotic pathogenesis.
  • Current early diagnosis and prevention strategies are limited.

Purpose of the Study:

  • To explore the role of intracellular redox status in atherosclerosis.
  • To evaluate the efficacy of targeting antioxidant enzymes in preventing ROS-related vascular disease.
  • To investigate the potential of antioxidant enzyme-mimetics as a therapeutic approach.

Main Methods:

  • Analysis of the role of intracellular oxidant and antioxidant systems.
  • Review of clinical trial data on antioxidant vitamins.
  • Examination of cellular antioxidant enzymes (superoxide dismutases, catalase, glutathione peroxidases, peroxiredoxins).

Main Results:

  • Imbalances in redox systems lead to oxidative or reductive stress, causing cellular damage.
  • Non-specific ROS scavenging with antioxidant vitamins has shown limited or harmful effects.
  • Cellular antioxidant enzymes offer localized regulation of ROS production.

Conclusions:

  • Targeting specific antioxidant enzymes presents a potential therapeutic avenue for preventing ROS-related atherosclerotic vascular disease.
  • Development of specific antioxidant enzyme-mimetics could enhance clinical effectiveness.
  • Further research into targeted antioxidant strategies is warranted for atherosclerotic disease management.
Keywords:
Antioxidant enzymesAntioxidant therapeuticsAtherosclerosisReactive oxygen speciesVascular disease

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