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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Exocytosis00:50

Exocytosis

Exocytosis is a process that releases molecules outside the cell. Like other bulk transport mechanisms, exocytosis requires energy.
Exocytosis is the opposite of endocytosis, which brings molecules inside the cell. Sometimes, the released materials are signaling molecules. For example, neurons typically use exocytosis to release neurotransmitters. Cells also use exocytosis to insert proteins such as ion channels into their cell membranes, secrete proteins for use in the extracellular matrix, or...
Exocytosis00:51

Exocytosis

Exocytosis is used to release material from cells. Like other bulk transport mechanisms, exocytosis requires energy.

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Related Experiment Video

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Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues
05:27

Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues

Published on: September 20, 2024

ExoCarta as a resource for exosomal research.

Richard J Simpson1, Hina Kalra, Suresh Mathivanan

  • 1Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.

Journal of Extracellular Vesicles
|September 7, 2013
PubMed
Summary

Exosomes, tiny vesicles involved in cell communication, have a new database called ExoCarta. This manually curated resource compiles exosomal proteins, RNA, and lipids from numerous studies to aid biomedical research.

Keywords:
Vesiclepediaexosome resourceexosome toolsextracellular organellesmicrovesicle database

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Last Updated: May 8, 2026

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Published on: September 20, 2024

Purification and microRNA Profiling of Exosomes Derived from Blood and Culture Media
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Tracking miRNA Release into Extracellular Vesicles using Flow Cytometry
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Area of Science:

  • Biochemistry
  • Cell Biology
  • Biotechnology

Background:

  • Exosomes are endosome-derived extracellular vesicles crucial for intercellular communication.
  • Their roles in drug delivery, disease biomarker discovery, and cell signaling generate significant research interest.
  • The increasing volume of exosomal data necessitates centralized, accessible repositories.

Purpose of the Study:

  • To introduce ExoCarta, a manually curated database of exosomal cargo.
  • To highlight the utility of ExoCarta for exosomal research.
  • To encourage researchers to contribute their exosomal datasets.

Main Methods:

  • Manual curation of exosomal proteins, RNA, and lipids from published and unpublished studies.
  • Integration of diverse datasets into a unified database.
  • Web-based accessibility of curated exosomal information.

Main Results:

  • ExoCarta provides a comprehensive resource of exosomal components.
  • The database integrates data from numerous exosomal studies.
  • ExoCarta has been accessed by over 16,000 unique users since its 2009 launch.

Conclusions:

  • ExoCarta is a valuable tool for advancing exosomal research.
  • Centralized data compilation enhances the utility of exosomal studies.
  • Direct data deposition by researchers is crucial for ExoCarta's continued growth and utility.