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Deformation in a Circular Shaft

Deformation in a Circular Shaft

One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...

Toroids

Toroids

A toroid is a closely wound donut-shaped coil constructed using a single conducting wire. In general, it is assumed that a toriod consists of multiple circular loops perpendicular to its axis.
When connected to a supply, the magnetic field generated in the toroid has field lines circular and concentric to its axis. Conventionally, the direction of this magnetic field is expressed using the right-hand rule. If the fingers of the right hand curl in the current direction, the thumb points in the...

The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

Torsional Pendulum

Torsional Pendulum

A torsional pendulum involves the oscillation of a rigid body in which the restoring force is provided by the torsion in the string from which the rigid body is suspended. Ideally, the string should be massless; practically, its mass is much smaller than the rigid body's mass and is neglected.
As long as the rigid body's angular displacement is small, its oscillation can be modeled as a linear angular oscillation. The amplitude of the oscillation is an angle. The role of mass is played by the...

Torsion of Noncircular Members

Torsion of Noncircular Members

Circular shafts undergoing torsional stress maintain their cross-sectional integrity due to their axisymmetric nature. This symmetry ensures an even distribution of stress, allowing the shaft to withstand torsion without distorting. In contrast, square bars, lacking this axial symmetry, experience significant distortion across their cross-sections when subjected to torsion, with the exception of along their diagonals and at lines connecting midpoints. A detailed examination of a cubic element...

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Updated: May 8, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

A new RING tossed into an old HAT.

Alison E Ringel¹, Cynthia Wolberger

¹Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Structure (London, England : 1993)

|September 10, 2013

Summary

This summary is machine-generated.

The study reveals a new RING domain in the p300 enzyme, a key regulator of gene expression implicated in cancer. This newly found domain controls the enzyme's activity.

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Aortic Ring Assay

Aortic Ring Assay

Published on: November 24, 2009

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Last Updated: May 8, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

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Published on: October 6, 2022

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Aortic Ring Assay

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Published on: November 24, 2009

Area of Science:

Biochemistry
Molecular Biology
Epigenetics

Background:

p300 and CBP are crucial histone acetyltransferases (HATs) involved in gene expression regulation.
Mutations in these HATs are linked to various human diseases, notably cancer.

Purpose of the Study:

To elucidate the structural basis of p300 catalytic activity.
To identify novel regulatory mechanisms of p300 function.

Main Methods:

X-ray crystallography was used to determine the structure of the p300 catalytic core.
Biochemical assays were performed to assess the activity of the identified domain.

Main Results:

The crystal structure of the p300 catalytic core was resolved.
A previously unrecognized RING domain was discovered within the p300 structure.
This novel RING domain was shown to regulate the histone acetyltransferase activity of p300.

Conclusions:

The discovery of the p300 RING domain provides new insights into the regulation of gene expression.
This finding may open new avenues for therapeutic strategies targeting p300 in cancer and other diseases.