Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The overnight dexamethasone test is a worthwhile screening procedure.

C Cronin1, D Igoe, M J Duffy

  • 1Department of Endocrinology and Diabetes Mellitus, St. Vincent's Hospital, Dublin, Republic of Ireland.

Clinical Endocrinology
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells.

British journal of cancer·2025
Same author

Mpox outbreak - Response and epidemiology of confirmed cases in Ireland from May 2022 to May 2023.

Irish medical journal·2024
Same author

A zinc phthalocyanine-benzoperylenetriimide conjugate for solvent dependent ultrafast energy vs. electron transfer.

Chemical communications (Cambridge, England)·2019
Same author

High Rates of Diabetic Ketoacidosis in Patients with New and Known Type 1 Diabetes over a Six-Year Period

Irish medical journal·2019
Same author

Integration of a recent infection testing algorithm into HIV surveillance in Ireland: improving HIV knowledge to target prevention.

Epidemiology and infection·2019
Same author

Diagnosis, misdiagnosis and management of hyperprolactinemia.

Expert review of endocrinology & metabolism·2019
Same journal

Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH.

Clinical endocrinology·2026
Same journal

Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases.

Clinical endocrinology·2026
Same journal

Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome.

Clinical endocrinology·2026
Same journal

Regarding Non-Classical Presentations of Rare Hereditary Hypoparathyroidism: A Case Series of CASR, GNA11, and GATA3 Mutations in Parathyroidology.

Clinical endocrinology·2026
Same journal

Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

Clinical endocrinology·2026
Same journal

Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

Clinical endocrinology·2026
See all related articles

The overnight low-dose dexamethasone test is a valuable screening tool for Cushing's syndrome. While some false positives occur, it effectively identifies most patients needing further evaluation.

Area of Science:

  • Endocrinology
  • Clinical Diagnostics

Background:

  • Cushing's syndrome diagnosis requires reliable screening.
  • The overnight low-dose dexamethasone test (OLDT) is a convenient alternative to traditional tests.

Purpose of the Study:

  • To evaluate the accuracy and utility of the OLDT for Cushing's syndrome screening.
  • To investigate claims of high false-positive rates in specific patient populations.

Main Methods:

  • Retrospective review of 100 consecutive patients undergoing OLDT.
  • Analysis of cortisol suppression and correlation with patient characteristics.

Main Results:

  • Cushing's syndrome confirmed in 4% of patients.
  • Normal cortisol suppression in 84% of patients.

Related Experiment Videos

  • 12% of patients showed false-positive results, not linked to weight or inpatient status.

    • Conclusions:

    • The OLDT is a useful screening procedure for Cushing's syndrome.
    • Approximately 12.5% of patients may require further testing to confirm or exclude the diagnosis.