[99mTc-MDP bolus in the treatment of bone metastasis]

From November 1988 to March 1989, 20 patients with serious multiple bone metastases were treated by high dose 99mTc-MDP bolus. In the adult, 99mTc-MDP at a dose of 200-300 mCi was injected intravenously and repeated at 24-48 hour intervals as a course. The total dose was 1,200 mCi. Subjective response rate was 100% and pain was relieved within 24 hours of the treatment in 55% of patients. The average and mean remission period was 60 days and 61 days, respectively. At least 50% of the treated patients did not require further analgesic treatment any more. Scintillation count rate ratio of the bone lesion to control was reduced by 32.13% after treatment. Repair of the destroyed bone was shown by X-ray films in some cases. No toxicity to the liver, kidney or marrow was observed.