Synthesis and anti-inflammatory activity of three nitro chalcones
Abraham Gómez-Rivera1, Hidemí Aguilar-Mariscal, Nancy Romero-Ceronio
1División Académica de Ciencias Básicas, Km 1 Carretera Cunduacán-Jalpa de M. Cunduacán, Tabasco 86690, Mexico.
Abstract:
The aim of this study was to synthesize three nitro substituted chalcones and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. The nitro chalcone were prepared by aldol condensation using of mechanical agitation and environmentally friendly solvents with 72-73% yields in approximately 2h. The three structures were evaluated on biological activity at dose of 200mg/kg and they showed anti-inflammatory protective effect by both oral and intraperitoneal administration, this effect was time dependent.
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