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Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss: a large cohort study
Kinue Katano1, Sadao Suzuki, Yasuhiko Ozaki
1Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
Objective:
To determine the predictive value of preconceptional peripheral blood natural killer (pNK) cell activity in patients with recurrent pregnancy loss (RPL).
Design:
Cohort study.
Setting:
University department.
Patient(S):
A total of 552 patients with a history of two to six consecutive miscarriages.
Intervention(S):
None.
Main Outcome Measure(S):
The predictive value of preconceptional pNK cell activity for subsequent miscarriage was analyzed using multivariable logistic regression analysis, with age, number of previous miscarriages, and presence/absence of previous live births and bed rest as covariates.
Result(S):
Age and number of previous miscarriages, but not high pNK cell activity, were found to be independent risk factors for a subsequent miscarriage. No effect of bed rest and previous live birth on the likelihood of live birth was observed (odds ratios 1.28 [95% confidence interval 0.81-2.02] and 0.91 [0.52-1.59], respectively).
Conclusion(S):
Elevated pNK cell activity was found to not be an independent risk factor for subsequent miscarriage. Clinicians should not measure the plasma NK activity as a systematic recurrent pregnancy loss examination, because its clinical significance is yet to be established.
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