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Advances in molecular and clinical subtyping of breast cancer and their implications for therapy
Karen A Cadoo1, Tiffany A Traina, Tari A King
1Breast Cancer Medicine Service, Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10065, USA.
Abstract:
The identification of the intrinsic molecular subtypes of breast cancer has enhanced our understanding of tumor biology, informing therapeutic targets, and clinical trial design. This article reviews the intrinsic classification system and the clinically defined subtypes of breast cancer. We review the molecular drivers of each subtype and discuss implications for prognosis, clinical management, and future directions.
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