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Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...

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Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
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Implant surface detoxification: a comprehensive review.

Fernando Suarez1, Alberto Monje, Pablo Galindo-Moreno

  • 1*Visiting Scholar, Graduate Periodontics, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI. †Professor, Department of Oral Surgery, University of Granada, Granada, Spain. ‡Professor and Director of Graduate Periodontics, Graduate Periodontics, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI.

Implant Dentistry
|September 10, 2013
PubMed
Summary
This summary is machine-generated.

Surgical treatment for peri-implantitis with bone loss requires implant surface detoxification. While various agents exist, current evidence suggests they are equally effective, though comparative studies have limitations.

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Area of Science:

  • Dental Implantology
  • Periodontology
  • Biomaterials Science

Background:

  • Nonsurgical treatments are effective for inflammatory lesions around implants without bone loss.
  • Surgical intervention may be necessary for peri-implantitis when bone loss is present.
  • Effective surgical treatment necessitates detoxification of the contaminated implant surface.

Purpose of the Study:

  • To review and evaluate various proposed agents and techniques for implant surface detoxification.
  • To assess the efficacy of different methods in achieving implant surface detoxification prior to surgical intervention.

Main Methods:

  • Comprehensive literature search of PubMed and hand-searched articles up to December 2011.
  • Inclusion of studies utilizing various keywords related to the treatment of peri-implant diseases.

Main Results:

  • All evaluated techniques and agents demonstrated equal effectiveness in detoxifying the contaminated implant surface.
  • A wide array of detoxification agents/techniques were considered, including chemical, physical, and energy-based methods.

Conclusions:

  • Current comparative studies on implant surface detoxification methods exhibit heterogeneity.
  • This heterogeneity creates uncertainties in selecting the optimal technique for detoxifying contaminated implant surfaces.
  • Further well-designed comparative studies are needed to guide clinical decision-making.