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Updated: May 8, 2026

07:57
A High-Throughput Comet Assay Approach for Assessing Cellular DNA Damage
Published on: May 10, 2022
Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication
Feng Wang1, Po-Jung Jimmy Huang, Juewen Liu
1Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. liujw@uwaterloo.ca.
Abstract:
The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, which might increase selectivity of cisplatin towards guanine over adenine.

