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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

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Related Experiment Video

Updated: May 8, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Gene expression and epigenetic deregulation.

Rita Shaknovich1

  • 1Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10021, USA, ris9004@med.cornell.edu.

Advances in Experimental Medicine and Biology
|September 10, 2013
PubMed
Summary
This summary is machine-generated.

DNA methylation is crucial for gene regulation and cancer development. Aberrant DNA methylation patterns are key in B-cell development and chronic lymphocytic leukemia (CLL) progression.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Related Experiment Videos

Last Updated: May 8, 2026

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • Recent discoveries highlight epigenetic mechanisms in gene regulation and genome organization.
  • DNA methylation plays a critical role in both normal development and cancer.
  • Genome-wide DNA methylation changes, such as hypermethylation of tumor suppressor genes and global hypomethylation, are significant drivers of gene dysregulation and chromosomal instability.

Purpose of the Study:

  • To provide an overview of DNA methylation patterns during B-cell development.
  • To summarize aberrant methylation changes contributing to lymphoid transformation and chronic lymphocytic leukemia (CLL).
  • To discuss deregulated biomarkers and pathways critical for lymphomagenesis.

Main Methods:

  • Review of established knowledge on DNA methylation patterns.
  • Analysis of aberrant methylation changes in lymphoid malignancies.
  • Integration of data from single-gene and genome-wide approaches.

Main Results:

  • DNA methylation patterns are established and maintained by specific machinery during B-cell development.
  • Aberrant methylation is implicated in the development of CLL.
  • Key biomarkers and critical pathways for lymphomagenesis have been identified.
  • Epigenetic differences correlate with known prognostic groups in CLL.

Conclusions:

  • Understanding DNA methylation dynamics is essential for comprehending B-cell development and CLL pathogenesis.
  • Aberrant epigenetic modifications represent crucial targets for therapeutic strategies in lymphoid malignancies.
  • Genome-wide and single-gene approaches provide complementary insights into epigenetic dysregulation in cancer.