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Phenolic compounds with IL-6 inhibitory activity from Aster yomena
A Ryun Kim1, Qinglong Jin, Hong-Guang Jin
1College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju, 501-759, Republic of Korea.
Archives of Pharmacal Research
|September 10, 2013
Summary
Researchers isolated a new biflavonoid, asteryomenin, and six known compounds from Aster yomena. Caffeic acid and apigenin showed potent inhibition of interleukin-6 (IL-6) production in TNF-α stimulated cells.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Immunology
Background:
- Aster yomena is a plant species with potential medicinal properties.
- Phenolic compounds and biflavonoids are known for their diverse biological activities.
- Interleukin-6 (IL-6) is a key cytokine involved in inflammatory processes.
Purpose of the Study:
- To isolate and identify chemical constituents from the aerial parts of Aster yomena.
- To evaluate the inhibitory activity of isolated compounds on IL-6 production.
- To explore potential anti-inflammatory agents from natural sources.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation of isolated compounds via 1D and 2D NMR spectroscopy (COSY, HSQC, HMBC, NOESY).
- In vitro assay to measure IL-6 production in TNF-α stimulated MG-63 cells.
Main Results:
- A new biflavonoid, asteryomenin (1), and six known phenolic compounds (2-7) were isolated.
- Compounds 2-7 were reported from Aster yomena for the first time.
- Caffeic acid (4) and apigenin (7) exhibited potent inhibition of IL-6 production.
- Compounds 1-3 and 5-6 showed moderate inhibitory activity.
Conclusions:
- Aster yomena is a source of diverse phenolic compounds with anti-inflammatory potential.
- Caffeic acid and apigenin demonstrate significant IL-6 inhibitory effects, suggesting therapeutic applications.
- Further research into these compounds could lead to novel anti-inflammatory drug development.
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