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Propofol for laryngeal mask airway insertion in children: Effect of two different doses

Mahin Seyedhejazi1, Mahmoud Eydi, Morteza Ghojazadeh

  • 1Tabriz University of Medical Sciences, Tabriz, Iran.

Saudi Journal of Anaesthesia
|September 10, 2013
PubMed

Insights

Two propofol doses (2.5 and 3.5 mg/kg) showed similar effectiveness for laryngeal mask airway (LMA) insertion in children. This study found no significant differences in complications or airway quality between the two propofol regimens.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery

Background:

  • Propofol facilitates laryngeal mask airway (LMA) insertion during anesthesia induction.
  • Optimal propofol dosage for LMA insertion in pediatric patients remains undetermined, balancing efficacy against potential complications.

Purpose of the Study:

  • To compare the efficacy and safety of two intravenous propofol doses (2.5 mg/kg vs. 3.5 mg/kg) for laryngeal mask airway (LMA) insertion in pediatric out-patients.

Main Methods:

  • A double-blind randomized clinical trial involving 120 children undergoing out-patient surgery.
  • Patients received pre-medication with midazolam, fentanyl, and lidocaine before induction with either 2.5 mg/kg or 3.5 mg/kg of propofol.
  • Comparison of hemodynamic changes, complications, airway quality, and LMA insertion success rate between the two propofol dose groups.

Main Results:

  • No significant differences were observed in hemodynamic parameters (blood pressure, heart rate) or peripheral oxygen saturation between the groups.
  • Intraoperative complications and the success rate of LMA insertion on the first attempt (93.2% vs. 91.5%) were comparable.
  • Adequate airway establishment was achieved in all patients in both the 2.5 mg/kg and 3.5 mg/kg propofol groups.

Conclusions:

  • Intravenous propofol doses of 2.5 mg/kg and 3.5 mg/kg are equally effective for laryngeal mask airway insertion in pediatric patients.
  • The chosen pre-medication regimen (midazolam, fentanyl, lidocaine) appears to support the efficacy of both propofol doses.
  • Both dosages are deemed safe and effective for this specific anesthetic procedure in children.
Abstract

Keywords:
Childrenlaryngeal mask airwaypropofol

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