Factors predicting mood changes in oral contraceptive pill users
Ghodratollah Shakerinejad1, Alireza Hidarnia, Mohammad Esmaeil Motlagh
1Department of Health Education, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Hidarnia@modares.ac.ir.
Reproductive Health
|September 11, 2013
Summary
Mood changes affect 37.7% of oral contraceptive pill (OCP) users. Factors like location, lack of side effect information, and lower self-efficacy predict these mood changes in women using OCPs.
Area of Science:
- Reproductive Health
- Women's Health
- Psychiatry
Background:
- Oral contraceptive pills (OCPs) are used by over 100 million women globally.
- Mood changes are a primary reason for OCP discontinuation.
- Understanding OCP-related mood changes is crucial for continued use and women's well-being.
Purpose of the Study:
- To determine the prevalence of mood changes in oral contraceptive pill users.
- To identify predicting factors associated with mood changes in OCP users.
Main Methods:
- A cross-sectional study involving 500 women aged 15-49 years using low-dose OCPs in Ahwaz, Iran.
- Data collected via face-to-face interviews using a structured questionnaire.
- Univariate and multiple logistic regression analyses were performed to identify significant predictors.
Main Results:
- 37.7% of women reported mood changes attributed to OCP use.
- Significant predictors included place of living (OR=2.57), not receiving OCP side effect information (OR=1.80), and lower self-efficacy (OR=0.87).
- These findings highlight key factors influencing mood alterations in OCP users.
Conclusions:
- The prevalence of OCP-related mood changes in Iranian women aligns with global findings.
- Receiving information on OCP side effects and higher self-efficacy are crucial protective factors.
- Implementing educational programs and enhancing self-efficacy are recommended to mitigate mood changes.
Related Concept Videos
Factors Affecting Drug Response: Overview
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
The Placebo Effect
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Factors Affecting Drug Biotransformation: Biological
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Therapeutic Drug Monitoring: Affecting Factors
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Factors Affecting Drug Distribution: Miscellaneous Factors
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...

