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Updated: May 8, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
[Risk factors related to mental disorder in patients with craniocerebral injury]
Shui-qin Xu1, San-mei Chen, Deng-ke Zhang
1Department of Nursing, Shaoxing University, Shaoxing, China. shuiqinxu@sina.com
Objective:
To explore the correlation between mental disorder and craniocerebral injury, and notifying its related risk factors.
Methods:
342 patients from Sep. 2008 to Sep. 2012 with craniocerebral injury were selected and related clinical data on general their conditions, including sex, age, educational level, satisfaction on careers and relations to family were collected. All the patients received CT-scans to the head, IQ test, MQ test, SCID-1/P, PDQC and SCICP detection. Multivariate logistic regression was used to analyze the general information and cerebral injurious conditions of patients regarding the incidence of mental disorders.
Results:
249 patients with mental disorder were noticed out of the total 342 patients with craniocerebral injury, with the incidence rate as 72.8% including 117 depression (47.0%), 95 anxiety disorders (38.2%), 27 mania (10.8%), 69 intelligence and memory disorders (27.7%) cases. Data from correlation analysis showed that factors as sex, age, educational level, satisfaction on careers and family of patients as well as type, severity and location of the craniocerebral injuries appeared to have important correlation with mental disorder.
Results:
also showed that the age of patients (OR > 1.04), severity and location of the craniocerebral injuries (OR1 > 1.28, OR2 > 1.31) were independent risk factors (P < 0.05).
Conclusion:
The age of patients, severity and location of the craniocerebral injuries were independent risk factors for mental disorder in patients with craniocerebral injury.
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