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Benign lymphoepithelial lesion with large cysts: case report.

S S Hong1, Y Ogawa, T Yagi

  • 1Department of Oral Pathology, Osaka University Medical School, Japan.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|July 1, 1990
PubMed
Summary

This case report details a benign lymphoepithelial lesion in a 60-year-old woman, presenting with parotid gland cysts and duct dilatation, mimicking Sjögren's syndrome. The cysts likely resulted from autoimmune-driven duct dilatation, with potential autoimmune involvement in a lymph node-related cyst.

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Area of Science:

  • Pathology
  • Immunology
  • Otolaryngology

Background:

  • Benign lymphoepithelial lesions (BLEL) are rare salivary gland tumors.
  • Sjögren's syndrome is an autoimmune disease affecting exocrine glands, often presenting with dry eyes and mouth.
  • Parotid gland cysts can occur in various conditions, including autoimmune disorders.

Observation:

  • A 60-year-old woman presented with clinical features suggestive of Sjögren's syndrome, excluding dry eyes.
  • Two large cysts (20 mm diameter) and multiple foci of duct dilatation were observed in the left parotid gland.
  • One cyst was located within a lymph node, suggesting a potential association with lymphoepithelial cysts.

Findings:

  • Surgical removal of the parotid gland cysts was performed.

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  • Histopathological examination revealed a benign lymphoepithelial lesion with significant ductal changes.
  • Human leukocyte antigen (HLA)-DR expression on the epithelium supports an autoimmune etiology for the duct dilatation and cyst formation.

    • Implications:

    • The findings suggest that autoimmune responses, potentially related to Sjögren's syndrome, can cause duct dilatation and cyst formation in the parotid gland.
    • The presence of a cyst within a lymph node highlights the complex interplay between autoimmune phenomena and pre-existing lesions.
    • This case contributes to understanding the pathogenesis of benign lymphoepithelial lesions and their association with autoimmune conditions.