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Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Atopy in Omani patients with asthma
Maha Al-Amri1, Omar A Al-Rawas, Bazdawi Ms Al-Riyami
1Department of ENT, Al-Nahda Hospital, Ministry of Health, PO Box 393, Muscat 113, Sultanate of Oman.
Journal for Scientific Research. Medical Sciences
|September 11, 2013
Summary
Serum immunoglobulin E (IgE) monitoring in Omani asthma patients can indicate atopy, especially when skin prick tests are not feasible. Clinical history is crucial for interpreting varied lab results.
Area of Science:
- Immunology
- Allergy Research
- Clinical Diagnostics
Background:
- Asthma is a common respiratory condition often associated with allergic sensitization.
- Serum immunoglobulin E (IgE) levels are a key biomarker in allergic diseases.
- Understanding IgE ranges in specific populations is vital for accurate diagnosis and management.
Purpose of the Study:
- To establish the normal range of serum IgE in healthy Omani subjects.
- To determine serum IgE levels in Omani asthmatic patients.
- To assess the degree of atopy in asthmatic patients using specific IgE tests.
Main Methods:
- Serum IgE levels were measured in 44 asthmatic patients and control groups.
- In vivo skin prick tests (SPT) were performed.
- In vitro ImmunoCAP tests for allergen-specific IgE were conducted.
Main Results:
- The normal serum IgE range in Oman was determined to be ≥ 101 IU/ml.
- Asthmatic patients showed a geometric mean IgE of 468 IU/ml.
- Atopy was prevalent, with 74% positive ImmunoCAP and 77% positive SPT results in asthmatics.
- Total serum IgE correlated with SPT reactivity (r=0.54, p<0.001).
Conclusions:
- Routine monitoring of total serum IgE can suggest atopy in asthmatics, particularly when SPT is not indicated.
- Laboratory results, including serum IgE and SPT, should be interpreted alongside clinical history due to potential discrepancies.
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