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Endothelial dysfunction in primary Sjögren syndrome.
1Etlik Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey. akyelahmet@gmail.com
Primary Sjögren syndrome disrupts endothelial function, indicated by impaired brachial artery flow-mediated dilation. However, carotid intima-media thickness remained similar between patients and healthy individuals, highlighting specific vascular abnormalities.
Area of Science:
- Vascular Biology
- Rheumatology
- Immunology
Background:
- Primary Sjögren syndrome is an autoimmune disorder affecting exocrine glands.
- Endothelial dysfunction is increasingly recognized as an early event in autoimmune diseases.
- Understanding vascular involvement is crucial for managing Sjögren syndrome complications.
Purpose of the Study:
- To investigate endothelial function in patients with primary Sjögren syndrome.
- To compare brachial artery flow-mediated dilation (FMD) and carotid intima-media thickness (CIMT) between patients and controls.
Main Methods:
- Recruited 35 patients with primary Sjögren syndrome and 20 healthy volunteers.
- Measured flow-mediated dilation of the brachial artery.
- Assessed carotid intima-media thickness.
Main Results:
- Flow-mediated dilation was significantly impaired in the primary Sjögren syndrome group (7%) compared to controls (12%, p=0.002).
- Carotid intima-media thickness was comparable between primary Sjögren syndrome patients and healthy controls (p > 0.05).
Conclusions:
- Patients with primary Sjögren syndrome exhibit endothelial dysfunction.
- This dysfunction is evident despite similar carotid intima-media thickness, suggesting specific early vascular changes.
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