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Related Experiment Videos

Bicarbonate excretion in kwashiorkor.

B Shine, P R Betts, M D Mann

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 9, 1975
    PubMed
    Summary

    Children with kwashiorkor experience impaired bicarbonate excretion, leading to acid urine despite alkalosis. This kidney function defect resolves with two weeks of treatment.

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    Area of Science:

    • Pediatric Nephrology
    • Nutritional Disorders

    Background:

    • Kwashiorkor, a severe form of malnutrition, is associated with metabolic disturbances.
    • Impaired renal function, specifically in acid-base balance, is a potential complication.

    Purpose of the Study:

    • To investigate the bicarbonate excretion defect in children with kwashiorkor.
    • To determine if this renal defect is reversible with treatment.

    Main Methods:

    • Assessment of renal bicarbonate excretion in pediatric patients diagnosed with kwashiorkor.
    • Monitoring of acid-base status and urine pH during and after nutritional therapy.

    Main Results:

    • Children with kwashiorkor demonstrated impaired bicarbonate excretion.
    • This resulted in the inappropriate excretion of acid urine even when systemic alkalosis was present.
    • The bicarbonate excretion defect resolved within two weeks of initiating treatment.

    Conclusions:

    • Kwashiorkor is associated with a transient impairment of renal bicarbonate excretion.
    • Nutritional rehabilitation effectively corrects this specific renal tubular dysfunction.

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