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Updated: May 8, 2026

Identifying Protein-protein Interaction Sites Using Peptide Arrays
Published on: November 18, 2014
The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions
Hadar Amartely1, Ahuvit David, Mario Lebendiker
1Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel. assaf.friedler@mail.huji.ac.il.
Abstract:
The STIL protein participates in mitosis and malignant transformation by regulating centrosomal duplication. Using biophysical methods we studied the structure and interactions of STIL. We revealed that its central domain is intrinsically disordered and mediates protein-protein interactions of STIL. The intrinsic disorder may provide STIL with the conformational flexibility required for its multitude binding.
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