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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Epidemiology, comorbidities, and healthcare utilization of patients with chronic urticaria in Germany.

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Updated: May 8, 2026

Basophil Activation Test for Allergy Diagnosis
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Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

[Useful tools for documenting urticaria].

P Staubach1, A Groffik

  • 1Hautklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland, petra.staubach@unimedizin-mainz.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 12, 2013
PubMed
Summary
This summary is machine-generated.

Urticaria patients experience a low quality of life due to chronic symptoms. Validated tools aid in diagnosing urticaria subtypes, assessing disease activity, and managing patient care effectively.

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Basophil Activation Test for Allergy Diagnosis
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Area of Science:

  • Dermatology
  • Inflammatory skin diseases
  • Urticaria research

Context:

  • Urticaria is a prevalent inflammatory skin condition affecting many patients long-term.
  • Urticaria significantly diminishes patients' quality of life and is linked to comorbidities.
  • Effective management requires accurate diagnosis and assessment of disease impact.

Purpose:

  • To outline a structured approach for diagnosing urticaria subtypes.
  • To detail methods for defining urticaria disease activity and intensity.
  • To analyze the impact of urticaria on patient quality of life and identify comorbidities.

Summary:

  • Validated evaluation tools, including urticaria activity scores and quality-of-life questionnaires, facilitate diagnosis and management.
  • Instruments like the Hamilton Anxiety Depression Scale (HADS) help confirm comorbidities such as anxiety and depression.
  • Diagnostic tools are crucial for assessing disease intensity, particularly in inducible urticaria cases.

Impact:

  • Enables efficient and accurate diagnosis and management of urticaria patients.
  • Supports clinical practice with easily learnable and employable assessment tools.
  • Improves patient outcomes by addressing disease severity and quality of life.