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Published on: January 7, 2019
Neurologic complications of infective endocarditis
Gauhar Chaudhary1, Jessica D Lee
1Department of Neurology, University of Kentucky College of Medicine, Lexington, 40536, USA.
Abstract:
Infective endocarditis is an infection of the inner surface or endocardium of the heart, in most instances involving the heart valves or the mural portion of the endocardium. As nonbacterial organisms such as rickettsia, fungi, and even viruses may also cause endocarditis, the term "infective endocarditis" is preferred over the older terminology of "bacterial endocarditis." Despite advancements in medical treatment and surgical therapies over the last few decades, infective endocarditis continues to be associated with a poor prognosis. There are many different factors affecting the clinical outcome in patient with infective endocarditis, including the type of organism and its virulence, patient characteristics, comorbid illness, time to diagnosis and treatment, indications for surgery, and time to surgery when indicated. In this article, we will review the epidemiology of endocarditis, the neurologic complications of infective endocarditis, and the current therapeutic strategies.
Insights
Infective endocarditis, an infection of the heart
Area of Science:
- Cardiology
- Infectious Diseases
- Neurology
Background:
- Infective endocarditis (IE) affects the heart's inner lining, often involving valves.
- The term "infective endocarditis" is preferred due to nonbacterial causes (fungi, viruses).
- Despite advances, IE prognosis remains poor, influenced by multiple factors.
Purpose of the Study:
- To review the epidemiology of infective endocarditis.
- To discuss the neurologic complications associated with IE.
- To outline current therapeutic strategies for IE.
Main Methods:
- Literature review of epidemiology.
- Analysis of factors influencing clinical outcomes.
- Summary of current treatment modalities.
Main Results:
- IE prognosis is multifactorial, depending on organism virulence, patient factors, and treatment timeliness.
- Neurologic complications are a significant concern in IE patients.
- Timely diagnosis and appropriate surgical intervention are crucial.
Conclusions:
- Infective endocarditis requires a comprehensive approach considering diverse influencing factors.
- Understanding epidemiology and neurologic risks is vital for patient management.
- Current therapeutic strategies aim to improve outcomes in this challenging condition.
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