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Related Concept Videos

Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...

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Updated: May 8, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
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Published on: May 16, 2020

Chemotherapy-induced Cardiotoxicity.

Maria Florescu1, Mircea Cinteza, Dragos Vinereanu

  • 1Emergency University Hospital, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Maedica
|September 12, 2013
PubMed
Summary
This summary is machine-generated.

Breast cancer chemotherapy can cause heart damage (cardiotoxicity) that current tests miss. Early detection methods are crucial for at-risk patients to prevent irreversible heart failure.

Keywords:
cardiotoxicitychemotherapynon-invasive methods

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Area of Science:

  • Oncology
  • Cardiology
  • Medical Imaging

Background:

  • Breast cancer is a leading cause of death in women globally.
  • Chemotherapy improves survival but can lead to cardiotoxicity, ranging from mild dysfunction to heart failure.
  • Current diagnostic methods for chemotherapy-induced cardiotoxicity fail to detect early, subtle changes.

Purpose of the Study:

  • To highlight the limitations of current diagnostic tools for chemotherapy-induced cardiotoxicity.
  • To emphasize the need for novel methods for early detection of cardiac dysfunction in breast cancer patients undergoing chemotherapy.
  • To identify patients at risk for irreversible heart failure and optimize treatment monitoring.

Main Methods:

  • Review of current diagnostic approaches for chemotherapy-induced cardiotoxicity.
  • Discussion of the limitations of traditional echocardiographic parameters.
  • Exploration of the necessity for advanced detection techniques.

Main Results:

  • Classical echocardiography cannot identify subclinical myocardial dysfunction.
  • Early detection of cardiac changes is essential for timely intervention.
  • Identifying at-risk patients can guide personalized treatment strategies.

Conclusions:

  • There is a critical need for advanced methods to detect early-stage cardiotoxicity in breast cancer patients.
  • Improved diagnostic tools will enable better patient risk stratification and treatment monitoring.
  • Early detection of cardiotoxicity is key to preventing irreversible heart failure and improving patient outcomes.