Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interplay between thermal contact and hormonal activity: A kinetic analysis on smartphone-induced endocrine disruption.

The Journal of steroid biochemistry and molecular biology·2026
Same author

Bisphenol S induces hepatic steatosis and insulin resistance through AMPK inhibition and endoplasmic reticulum stress.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

Microplastics and the Endocrine-Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid-Adipose Axis.

Environmental toxicology·2026
Same author

Bisphenol S and high-fat diet drive structural and inflammatory remodeling of the colon in C57Bl/6 male mice.

Toxicology letters·2026
Same author

Kinetic management of endocrine disruption: How chemical dynamics shape hormonal systems.

Molecular and cellular endocrinology·2026
Same author

Sex differences in thyroid function: from central regulation to hormone metabolism and disease susceptibility.

The Journal of endocrinology·2025

Related Experiment Video

Updated: May 8, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Flavonoid rutin increases thyroid iodide uptake in rats.

Carlos Frederico Lima Gonçalves, Carlos Frederico Lima Gonçalves1, Maria Carolina de Souza dos Santos

  • 1Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.

Plos One
|September 12, 2013
PubMed
Summary

Rutin, a dietary flavonoid, enhances thyroid iodide uptake in rats by increasing sodium-iodide symporter (NIS) expression. This suggests rutin could be a valuable adjuvant for radioiodine therapy in thyroid cancer patients.

Related Experiment Videos

Last Updated: May 8, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Nutritional Science

Background:

  • Thyroid iodide uptake via the sodium-iodide symporter (NIS) is crucial for thyroid hormone synthesis and radioiodine therapy effectiveness.
  • Reduced iodide uptake in some thyroid cancers leads to radioiodine therapy resistance, impacting patient survival.
  • Flavonoids, dietary compounds, show in vitro potential to modulate NIS and thyroid function, but in vivo data are limited.

Purpose of the Study:

  • To investigate the in vivo effects of dietary flavonoids on thyroid iodide uptake in Wistar rats.
  • To evaluate the impact of the most effective flavonoid, rutin, on thyroid hormone synthesis and metabolism.

Main Methods:

  • Administration of various flavonoids to Wistar rats to assess their effect on thyroid iodide uptake.
  • In-depth analysis of rutin's impact on serum thyroid hormones (T4, T3), thyrotropin (TSH), and deiodinase activities (Types 1 and 2).
  • Evaluation of sodium-iodide symporter (NIS) and TSH receptor expression in response to rutin treatment.

Main Results:

  • Rutin was the only flavonoid tested that significantly increased thyroid iodide uptake in vivo.
  • Rutin treatment resulted in a slight decrease in serum T4 and T3 without altering TSH levels.
  • Rutin modulated deiodinase activities, increasing Type 2 and decreasing Type 1, and enhanced NIS and TSH receptor expression.

Conclusions:

  • Rutin effectively increases thyroid iodide uptake in vivo, likely through enhanced NIS expression potentially secondary to TSH receptor upregulation.
  • Rutin demonstrates potential as an adjuvant therapy for radioiodine treatment by improving iodide uptake without significantly impairing thyroid function.
  • Further research into rutin's role in thyroid cancer management and radioiodine therapy is warranted.