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Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Pseudomyxoma peritonei originating from an intestinal duplication.
Julie Lemahieu1, André D'Hoore, Stijn Deloose
1Department of Imaging and Pathology, University Hospitals Leuven, Minderbroedersstraat 12, 3000 Leuven, Belgium.
Case Reports in Pathology
|September 12, 2013
Summary
This case report details an extremely rare instance of pseudomyxoma peritonei (PMP) originating from a small intestinal duplication. The study highlights a unique cause for this uncommon condition, emphasizing the importance of considering rare origins.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Background:
- Alimentary tract duplications are rare congenital anomalies, typically presenting in childhood.
- Pseudomyxoma peritonei (PMP) is an uncommon condition, usually arising from appendiceal neoplasms.
- Malignant transformation of intestinal duplications is exceptionally rare.
Purpose of the Study:
- To report an extremely unusual case of PMP originating from a small intestinal duplication.
- To describe the clinical presentation, diagnostic process, and histopathological findings.
- To elucidate the pathogenesis of PMP in this unique context.
Main Methods:
- Case report of a 67-year-old woman with abdominal pain.
- Explorative laparoscopy revealing diffuse peritoneal implants.
- Histopathological examination of resected cystic lesion and peritoneal implants.
- Surgical resection of a mesenteric cystic lesion.
Main Results:
- Diagnosis of low-grade PMP (disseminated peritoneal adenomucinosis) was established.
- No primary tumor was initially identified.
- A resected small intestinal duplication cyst revealed a low-grade villous adenoma.
- The adenoma led to a mucocele, causing noninvasive mucinous peritoneal implants.
Conclusions:
- A small intestinal duplication with a villous adenoma can be a rare primary source of PMP.
- This case expands the known etiologies of PMP.
- Understanding rare origins is crucial for accurate diagnosis and management of PMP.
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