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Updated: Aug 19, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Atypical Lentiginous Melanocytic Proliferations Case Series: Relationship to Type II Dysplastic Nevi and Lentiginous
Maged Daruish1,2, Ella De Ryck3, Laura Gadeyne4
1Cellular Pathology Department, Dorset County Hospital, Dorchester, UK.
Abstract:
A recent study described a distinctive subset of dysplastic nevi in older patients, genetically characterized by non-BRAFV600E driver mutations and frequent TERT promoter mutations. It has been proposed that these lesions overlap with the so-called lentiginous dysplastic nevi of the elderly. We explore this relationship in a series of 24 atypical lentiginous melanocytic proliferations, correlating with ex vivo dermoscopy, as well as immunohistochemical and molecular findings. We also discuss the utility of the MPATH-Dx tool to improve consensus for such lesions.
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