Related Experiment Video
Updated: May 8, 2026
03:43
Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
Towards a better cannabis drug
Raphael Mechoulam1, Linda Parker
1Institute for Drug Research, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
British Journal of Pharmacology
|September 13, 2013
Summary
Cannabidiol, a non-psychoactive cannabis compound, was found to counteract some memory impairments caused by tetrahydrocannabinol in rhesus monkeys. This research highlights potential therapeutic applications for cannabis constituents in managing cognitive effects.
Area of Science:
- Neuroscience
- Pharmacology
- Cannabis Research
Background:
- Commentary on Wright et al. study investigating cannabis constituent effects.
- Focuses on the interaction between cannabidiol and tetrahydrocannabinol on memory.
Purpose of the Study:
- To discuss the significance of a study examining how cannabidiol affects memory deficits induced by tetrahydrocannabinol.
- To highlight the opposing effects of cannabidiol on tetrahydrocannabinol-induced behavioral and memory disruptions.
Main Methods:
- Analysis of a study involving male rhesus monkeys.
- Assessment of behavioral and memory disruption caused by Δ(9)-tetrahydrocannabinol.
- Evaluation of the counteracting effects of cannabidiol.
Main Results:
- Cannabidiol partially opposes memory deficits induced by Δ(9)-tetrahydrocannabinol.
- The non-psychoactive cannabis constituent, cannabidiol, shows specific effects on memory disruption.
- Not all forms of behavioral and memory disruption were attenuated.
Conclusions:
- Cannabidiol demonstrates a capacity to mitigate certain cognitive impairments associated with Δ(9)-tetrahydrocannabinol.
- The findings suggest a complex interaction between different cannabis constituents and memory functions.
- Further research is warranted to explore the therapeutic potential of cannabidiol.
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
01:26Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
01:30Prodrugs
Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
Prodrugs help overcome...
Prodrugs help overcome...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
01:03Drug Control Governance: Regulatory Bodies and Their Impact
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...