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Published on: June 18, 2021
In-hospital cardiac complications after intracerebral hemorrhage
J Putaala1, M Lehto, A Meretoja
1Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Insights
Intracerebral hemorrhage patients face a 4% risk of serious cardiac events, including heart failure and arrhythmias. A history of myocardial infarction or new-onset atrial fibrillation significantly increases this risk.
Area of Science:
- Cardiology
- Neurology
- Internal Medicine
Background:
- Cardiac complications following intracerebral hemorrhage (ICH) are not well-documented.
- Understanding these events and their triggers is crucial for patient management.
Purpose of the Study:
- To determine the incidence of serious in-hospital cardiac events after ICH.
- To identify risk factors associated with these cardiac complications.
Main Methods:
- Retrospective analysis of 948 patients with nontraumatic ICH.
- Definition of serious cardiac events included myocardial infarction, ventricular arrhythmias, heart failure, and cardiac death.
- Multivariable logistic regression analysis to identify independent risk factors.
Main Results:
- 4.1% of patients experienced at least one serious in-hospital cardiac event.
- Acute heart failure was the most common complication (36 patients).
- History of myocardial infarction and atrial fibrillation (new-onset or pre-existing) were independently associated with increased risk.
Conclusions:
- Approximately 4% of patients with ICH experience significant cardiac complications during hospitalization.
- Patients with a prior myocardial infarction or developing atrial fibrillation during their hospital stay are at higher risk.
Background And Purpose:
Data on cardiac complications and their precipitants after intracerebral hemorrhage are scarce. We examined the frequency and risk factors for serious in-hospital cardiac events in a large cohort of consecutive intracerebral hemorrhage patients.
Methods:
A retrospective chart review of 1013 consecutive patients with nontraumatic intracerebral hemorrhage treated at the Helsinki University Central Hospital (2005-2010). We excluded patients with intraparenchymal hematoma related to sub-arachnoid hemorrhage or intracerebral hemorrhage because of fibrinolytic therapies for acute ischemic stroke or myocardial infarction. Serious in-hospital cardiac event was defined as any of in-hospital poststroke acute myocardial infarction, ventricular fibrillation or tachycardia, moderate to serious acute heart failure, or cardiac death.
Results:
Among the 948 patients included, ≥1 serious in-hospital cardiac event occurred in 39 (4·1%) patients after a median delay of two-days from stroke onset (acute myocardial infarction in three patients, ventricular fibrillation or tachycardia in three patients, acute heart failure in 36 patients, and cardiac death in three patients). Hospital stay was longer in patients with serious in-hospital cardiac event than in those without (median 12, interquartile range 7-19 vs. 8, 3-14; P = 0·001), with no difference in in-hospital mortality (23·1% vs. 24·3%; P = 0·86). In multivariable logistic regression analysis adjusted for age, gender, and diabetes, atrial fibrillation during hospitalization (odds ratio 6·68 for new-onset atrial fibrillation, 95% confidence interval 2·11-21·18; 4·46 for old atrial fibrillation, 2·08-9·56), and history of myocardial infarction (3·20, 1·18-8·66) were independently associated with serious in-hospital cardiac events.
Conclusions:
After intracerebral hemorrhage, 4% of patients suffer an acute serious cardiac complication. Those with history of myocardial infarction or in-hospital atrial fibrillation are at greater risk for such events.
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