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Related Concept Videos

Lipids as Anchors01:32

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...
Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
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IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
Membrane Domains01:18

Membrane Domains

The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
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Assembly of the Lipid Bilayer in the ER

Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
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Updated: May 8, 2026

Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting (LIMACS): a Novel Method to Analyze Protein-lipid Interaction
07:33

Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting (LIMACS): a Novel Method to Analyze Protein-lipid Interaction

Published on: April 26, 2011

Ceramide in the prostate.

Paul Dent1

  • 1Department of Neurosurgery; Massey Cancer Center; Virginia Commonwealth University; Richmond, VA USA.

Cancer Biology & Therapy
|September 13, 2013
PubMed
Summary
This summary is machine-generated.

This study investigates the role of I2PP2A in prostate cancer, finding that ceramide can reduce oncogene c-Myc accumulation by inhibiting I2PP2A and activating protein phosphatase 2A (PP2A). Ceramide also blocks I2PP2A

Keywords:
c-Myccell signalingceramidehistone acetyl transferaseinhibitor 2 of protein phosphatase 2Aprotein phosphatase 2Atumor suppressor lipid

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • Protein phosphatase 2A (PP2A) is a tumor suppressor.
  • I2PP2A (SET) is an oncogenic protein inhibiting PP2A and histone acetylation, overexpressed in tumors.
  • Ceramide regulates PP2A activity via I2PP2A and direct enzyme complex interactions.

Purpose of the Study:

  • Examine I2PP2A expression in prostate cancer.
  • Determine if ceramide reduces oncogene c-Myc via I2PP2A inhibition and PP2A activation.
  • Investigate ceramide's effect on I2PP2A's epigenetic action.

Main Methods:

  • Analysis of I2PP2A expression in prostate cancer and epithelial cells.
  • Assessment of ceramide's impact on c-Myc levels.
  • Evaluation of ceramide's influence on PP2A activity and histone acetylation.

Main Results:

  • I2PP2A expression was examined in prostate cancer.
  • Ceramide was found to decrease c-Myc accumulation by inhibiting I2PP2A and activating PP2A.
  • Ceramide's ability to block I2PP2A's epigenetic effects was investigated.

Conclusions:

  • Ceramide shows potential in targeting I2PP2A and c-Myc in prostate cancer.
  • Findings suggest ceramide's therapeutic relevance in modulating PP2A and epigenetic pathways.
  • Further research into ceramide's role in prostate cancer epigenetics is warranted.