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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Videos

Personalizing therapy for colorectal cancer.

Ashley Wong1, Brigette B Y Ma1

  • 1Sir Y. K. Pao Centre for Cancer, Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, China.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|September 13, 2013
PubMed
Summary

Personalized medicine advances colorectal cancer (CRC) treatment by tailoring therapies based on molecular profiles. This review details key discoveries driving individualized drug selection for better patient outcomes in CRC management.

Keywords:
5-FU5-fluorouracilCICIMPCRCColorectal CancerCpG island methylator phenotypeEGFRGene SignaturesHRKRAS MutationMSIOSPFSPI3KVEGFVEGFRcolorectal cancerconfidence intervalepidermal growth factor receptorhazard ratiomicrosatellite instabilityoverall survivalphosphoinositide 3-kinaseprogression-free survivalvascular endothelial growth factorvascular endothelial growth factor receptor

Related Experiment Videos

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Colorectal cancer (CRC) is a leading global cancer diagnosis.
  • Significant molecular biology discoveries have reshaped CRC clinical practice.

Purpose of the Study:

  • To review the progress of personalized medicine in contemporary colorectal cancer management.
  • To highlight key molecular discoveries impacting CRC treatment strategies.

Main Methods:

  • Review of comprehensive genome-wide profiling data (Cancer Genome Atlas Network).
  • Analysis of mutations in the RAS-RAF signaling pathway.
  • Elucidation of molecular subsets and gene signatures for predicting chemotherapy response.
  • Investigation of vascular endothelial growth factor (VEGF) pathway targeting.

Main Results:

  • Identification of RAS-RAF pathway mutations as key predictors for epidermal growth factor receptor (EGFR) antibody response.
  • Discovery of molecular subsets and gene signatures that predict outcomes after adjuvant chemotherapy.
  • Advancements in targeting VEGF and its receptors for CRC therapy.
  • Enabling individualized drug therapy based on tumor molecular profiles, particularly for metastatic CRC.

Conclusions:

  • Molecular profiling allows oncologists to personalize drug therapy for colorectal cancer patients.
  • Personalized medicine represents a significant advancement in managing metastatic colorectal cancer.
  • Continued research into molecular targets promises further improvements in CRC treatment and patient outcomes.