Clofazamine-induced generalized retinal degeneration

Clofazamine is an iminophenazine dye with antimycobacterial activity which has recently been used to treat mycobacterium avium complex infections in patients with acquired immunodeficiency syndrome. The authors present the second report of a presumed clofazamine-induced bull's-eye maculopathy and generalized retinal degeneration in a patient with AIDS. The importance of closely following patients on clofazamine, especially those with AIDS who may be particularly susceptible to developing this toxicity, is stressed.