Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clofazamine-induced generalized retinal degeneration.

C A Cunningham1, D N Friedberg, R E Carr

  • 1Department of Ophthalmology, New York University Medical Center, NY 10016.

Retina (Philadelphia, Pa.)
|January 1, 1990
PubMed
Summary

Clofazamine, used for Mycobacterium avium complex infections in AIDS patients, may cause bull's-eye maculopathy and retinal degeneration. Close monitoring of patients on clofazamine is crucial due to potential ocular toxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic changes in spatial representation within the posterior parietal cortex in response to visuomotor adaptation.

Cerebral cortex (New York, N.Y. : 1991)·2022
Same author

Foveal sensitivity changes in retinitis pigmentosa.

Applied optics·2010
Same author

Eccentricity-dependent changes in local onset and offset responses in patients with progressive cone dystrophy.

Vision research·2007
Same author

Multifocal visual evoked potentials to cone specific stimuli in patients with retinitis pigmentosa.

Vision research·2005
Same author

Atypical multifocal ERG responses in patients with diseases affecting the photoreceptors.

Vision research·2004
Same author

Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro.

Cancer biology & therapy·2004

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pharmacology

Background:

  • Clofazamine is an iminophenazine dye with antimycobacterial properties.
  • It is increasingly used for Mycobacterium avium complex (MAC) infections, particularly in patients with acquired immunodeficiency syndrome (AIDS).

Observation:

  • This report details the second case of presumed clofazamine-induced ocular toxicity.
  • The patient, diagnosed with AIDS, exhibited bull's-eye maculopathy and generalized retinal degeneration.

Findings:

  • Clofazamine administration was associated with the development of bull's-eye maculopathy.
  • Generalized retinal degeneration was also observed, suggesting a broader toxic effect on the retina.

Implications:

Related Experiment Videos

  • Patients with AIDS may be more susceptible to clofazamine-induced ocular toxicity.
  • Regular ophthalmological monitoring is essential for patients, especially those with AIDS, receiving clofazamine treatment.
  • Early detection and intervention can mitigate vision loss from this drug-induced retinopathy.