Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Understanding Outcomes in Hemodialysis Patients Who Underwent Transcatheter Aortic Valve Replacement With the Latest Devices.

JACC. Asia·2026

Same author

Health Status Changes and Long-Term Clinical Outcomes in Patients With Atrial Fibrillation.

JAMA network open·2026

Same author

Sex differences in circulating microRNA profiles in heart failure with preserved and reduced ejection fraction.

European heart journal open·2026

Same author

Serial Assessment of Patient-Reported Health Status and Subsequent Clinical Outcomes in Atrial Fibrillation.

Circulation journal : official journal of the Japanese Circulation Society·2026

Same author

7-Year Outcomes of Balloon-Expandable Versus Self-Expanding Valves in Women Undergoing Transcatheter Aortic Valve Replacement.

JACC. Asia·2026

Same author

Percutaneous closure strategy in patients with patent foramen ovale and coexisting small atrial septal defect: a single-center experience.

Cardiovascular intervention and therapeutics·2026

Search research articles

Related Experiment Video

Updated: May 8, 2026

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

Published on: January 23, 2016

Heart development and regeneration via cellular interaction and reprogramming.

¹Department of Clinical and Molecular Cardiovascular Research, School of Medicine, Keio University, Tokyo, Japan.

The Keio Journal of Medicine

|September 13, 2013

Summary

This summary is machine-generated.

Understanding heart development and cell interactions is key to regenerating damaged hearts. New research shows cardiac fibroblasts can be reprogrammed into cardiomyocyte-like cells, offering future therapeutic potential for heart disease.

More Related Videos

Intrathoracic Injection for the Study of Adult Zebrafish Heart

Intrathoracic Injection for the Study of Adult Zebrafish Heart

Published on: May 14, 2019

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Published on: March 17, 2020

Related Experiment Videos

Last Updated: May 8, 2026

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

Published on: January 23, 2016

Intrathoracic Injection for the Study of Adult Zebrafish Heart

Intrathoracic Injection for the Study of Adult Zebrafish Heart

Published on: May 14, 2019

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging

Published on: March 17, 2020

Area of Science:

Cardiovascular Biology
Developmental Biology
Regenerative Medicine

Background:

Adult cardiomyocytes are terminally differentiated, and their loss due to heart damage is irreversible.
Understanding heart development and cell-cell interactions is crucial for cardiac regeneration.
Cardiac innervation and fibroblast roles in heart development are areas of active investigation.

Purpose of the Study:

To elucidate the roles of cell-cell interactions in heart development and function.
To explore the potential of cardiac fibroblasts for regenerative therapies.

Main Methods:

Analysis of neural chemoattractant (nerve growth factor) and chemorepellent (Sema3a) balance in cardiac innervation.
Investigation of cardiac fibroblast-secreted factors in embryonic cardiomyocyte proliferation and chamber expansion.
Direct reprogramming of cardiac fibroblasts into cardiomyocyte-like cells in vitro and in vivo using cardiac-specific transcription factors.

Main Results:

A balance between neural chemoattractants and chemorepellents from cardiomyocytes is essential for proper cardiac innervation.
Cardiac fibroblasts secrete factors that promote embryonic cardiomyocyte proliferation and ventricular development.
Cardiac fibroblasts can be successfully reprogrammed into cardiomyocyte-like cells, demonstrating a novel regenerative strategy.

Conclusions:

Cell-cell interactions, including neural signaling and fibroblast activity, play critical roles in heart development.
Cardiac fibroblast reprogramming offers a promising avenue for future therapeutic strategies in treating heart disease.
Further research into heart development mechanisms and reprogramming technologies may lead to new treatments for cardiac damage.