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Updated: May 8, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
[The use of iontophoresis in corneal crosslinking technique]
Horia T Stanca1, Bogdana Tabacaru
1Spitalul Clinic de Urgenţa Prof. Dr. Agrippa Ionescu, Bucureşti.
Abstract:
Iontophoresis is a method of facilitating the penetration of a drug through an intact tissue in the presence of an low intensity electrical current. In corneal crosslinking technique, iontophoresis is used for transepitelial impregnation of cornea with riboflavin. Compared to passive technique of corneal impregnation, iontophoresis shortens the time needed for impregnation, the time of exposure to UVA radiation and does not require de-epithelialisation.
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