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Related Experiment Video

Updated: May 7, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

A model system for primary abdominal closures.

Michael J Yost1, Mary O Morales, Veronica Rodriguez-Rivera

  • 1Department of General Surgery, Medical University of South Carolina, Charleston, SC, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 14, 2013
PubMed
Summary
This summary is machine-generated.

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The foreign body response hinders medical implants and regenerative therapies. This study explores using skeletal muscle satellite cells to potentially inhibit this response and improve outcomes.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • The foreign body response (FBR) to implanted medical devices and regenerative therapies causes scarring and device failure.
  • Current therapies to mitigate FBR are limited and often unsafe.
  • FBR can inhibit the intended regenerative repair from cellularized implants and stem cells.

Purpose of the Study:

  • To investigate the cellular mechanisms underlying the foreign body response.
  • To explore the potential of skeletal muscle satellite cells in modulating FBR.
  • To determine if manipulating cell-cell communication can inhibit FBR for improved regenerative medicine outcomes.

Main Methods:

  • Developed an explant method to isolate, sort, enrich, and culture skeletal muscle satellite cells.

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Use of a Rat Model to Study Ventral Abdominal Hernia Repair
05:47

Use of a Rat Model to Study Ventral Abdominal Hernia Repair

Published on: October 2, 2017

Related Experiment Videos

Last Updated: May 7, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
20:33

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing

Published on: July 4, 2019

Use of a Rat Model to Study Ventral Abdominal Hernia Repair
05:47

Use of a Rat Model to Study Ventral Abdominal Hernia Repair

Published on: October 2, 2017

  • Utilized satellite cells, which are quiescent progenitor cells activated by muscle damage.
  • Investigated satellite cell behavior and their role in skeletal muscle repair and regeneration.

    • Main Results:

    • Satellite cells are heterogeneous populations of stem and progenitor cells.
    • The study established a model system using cultured satellite cells to study cellular responses.
    • The research aims to determine if manipulating satellite cell communication can reduce FBR.

    Conclusions:

    • Modifying the body's reaction to implanted materials is a critical therapeutic goal.
    • Skeletal muscle satellite cells offer a potential avenue for inhibiting FBR.
    • Further research into cell-cell communication may lead to advanced regenerative therapies.