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Updated: May 7, 2026
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
Cardiac wound healing post-myocardial infarction: a novel method to target extracellular matrix remodeling in the
Rogelio Zamilpa1, Jianhua Zhang, Ying Ann Chiao
1Division of Geriatrics, Gerontology and Palliative Medicine, Department of Medicine, Barshop Institute of Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.
Abstract:
Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.
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