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Related Concept Videos

Precipitation Gravimetry01:03

Precipitation Gravimetry

Precipitation gravimetry is based on converting an analyte into a sparingly soluble precipitate, which is separated by filtration and weighed. An ideal precipitate should be pure, insoluble, of known composition, and easily filtered from the reaction mixture.
In determining nickel by gravimetric analysis, a precipitant of ethanolic dimethylglyoxime is added to a hot nickel salt solution. This is quickly followed by the dropwise addition of dilute ammonia solution until precipitation occurs. A...
Masking and Demasking Agents01:19

Masking and Demasking Agents

EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on the metal...
Electrodeposition01:08

Electrodeposition

Electrodeposition is a technique used to separate an analyte from interferents by electrochemical processes. Here, the analyte is a metal ion that can be deposited on an electrode immersed in the sample solution. The electrochemical setup consists of an anode and a cathode. When an electric current is applied to the setup, oxidation occurs at the anode. At the cathode, which consists of a large metal surface, metal ions undergo reduction and deposit onto the surface.
Electrodeposition can...
Types of Reversible Electrodes01:24

Types of Reversible Electrodes

For electrode reversibility to be maintained, all the reactants and products involved in the half-reaction must be present at the electrode. There are several types of reversible electrodes (half-cells).In metal-metal-ion electrodes, a metal balances electrochemically with a solution of its own ions. Examples are Cu2+|Cu and Zn2+|Zn. Metals that react with the solvent, like group 1 and most group 2 metals, which react with water, and zinc, which reacts with aqueous acidic solutions, cannot be...
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
EDTA: Direct, Back-, and Displacement Titration01:30

EDTA: Direct, Back-, and Displacement Titration

The EDTA titration types for metal ion analysis include direct titration, back-titration, and replacement titration.
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides and...

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Related Experiment Video

Updated: May 7, 2026

Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants
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Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants

Published on: March 7, 2025

Contact alternatives to nickel.

Rajiv I Nijhawan1, Sharon E Jacob

  • 1From the *Department of Dermatology, St Luke's-Roosevelt Hospital Center, NewYork, NY; and †Division of Dermatology, University of California, San Diego - Rady Children's Hospital.

Dermatitis : Contact, Atopic, Occupational, Drug
|September 14, 2013
PubMed
Summary

Nickel allergy, a persistent global health issue, is the most common allergen. Rising allergic contact dermatitis rates underscore the need for nickel avoidance and exploring alternatives.

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Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Nickel allergy is a significant and widespread international health concern.
  • It has been identified as the most prevalent allergen for the past 30 years.
  • Recent data indicate a notable increase in positive patch-test reactions to nickel.

Purpose of the Study:

  • To acknowledge the growing problem of nickel allergy.
  • To emphasize the importance of nickel avoidance strategies.
  • To introduce potential alternatives to nickel exposure.

Main Methods:

  • Review of epidemiological data on nickel allergy.
  • Analysis of patch-test reaction rates from major dermatology groups.
  • Literature review on nickel's prevalence and impact.

Main Results:

  • Nickel remains the leading cause of allergic contact dermatitis globally.
  • Positive patch-test rates for nickel have significantly increased over the last decade.
  • The American Contact Dermatitis Society designated nickel as the 2008 Allergen of the Year.

Conclusions:

  • Nickel allergy poses a substantial and increasing public health challenge.
  • Effective nickel avoidance is crucial for managing allergic contact dermatitis.
  • Further research into nickel-free alternatives is warranted.