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Updated: May 7, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Current strategies in meniscal regeneration.

Jahid Hasan¹, John Fisher, Eileen Ingham

¹Institute of Medical and Biological Engineering, Schools of Biomedical Sciences and Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

|September 14, 2013

Summary

Meniscus injuries often lead to osteoarthritis, and current surgical repairs face limitations due to poor healing. Tissue engineering offers promising meniscus replacement strategies, but clinical application faces significant hurdles.

Keywords:

meniscus regenerative medicine scaffolds tissue engineering

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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

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Published on: May 21, 2013

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Last Updated: May 7, 2026

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Area of Science:

Orthopedics
Biomedical Engineering
Regenerative Medicine

Background:

The meniscus is crucial for knee joint biomechanics and tribology.
Meniscal damage is a significant risk factor for osteoarthritis development.
Arthroscopic surgery for meniscal injury is a common orthopedic procedure, yet healing is limited to vascularized areas.

Purpose of the Study:

To explore tissue engineering strategies for meniscus repair and replacement.
To address the limitations of current meniscal repair techniques.
To investigate novel approaches for treating meniscal injuries.

Main Methods:

Review of current tissue engineering strategies for meniscus regeneration.
Analysis of challenges in achieving functional meniscus replacement.
Evaluation of barriers to clinical translation of these technologies.

Main Results:

Tissue engineering shows potential for meniscus repair and replacement.
Limited healing capacity of the avascular meniscus remains a key challenge.
Significant barriers hinder the clinical application of engineered meniscus tissues.

Conclusions:

Tissue engineering holds promise for addressing meniscal deficiency.
Overcoming biological and technical challenges is essential for clinical success.
Further research is needed to translate these promising strategies into effective patient treatments.