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Increase resistant rates and ESBL production between E. coli isolates causing urinary tract infection in young

Babak Pourakbari1, Farzad Ferdosian, Shima Mahmoudi

  • 1Pediatrics Infectious Diseases Research Center, Tehran University of Medical Sciences , Tehran , Iran.

Brazilian Journal of Microbiology : [Publication of the Brazilian Society for Microbiology]
|September 14, 2013
PubMed

Insights

High rates of antimicrobial resistance and Extended-spectrum beta-lactamase producing Escherichia coli were found in pediatric urinary tract infections (UTI). Local surveillance is crucial for effective empirical therapy in children.

Area of Science:

  • Microbiology
  • Pediatric Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Urinary tract infections (UTI) caused by Extended-spectrum beta-lactamase (ESBL) producing Escherichia coli are a growing global health concern.
  • Increasing antimicrobial resistance limits treatment options for pediatric UTIs.

Purpose of the Study:

  • To investigate the prevalence of antimicrobial resistance and ESBL production in E. coli isolates from pediatric UTI cases.
  • To assess the susceptibility patterns of common antibiotics against these isolates.

Main Methods:

  • Disk diffusion method was used to test antibiotic susceptibility of 100 E. coli isolates from pediatric UTI patients.
  • Isolates were collected from patients aged 2 months to 12 years between April 2009 and March 2010.

Main Results:

  • High resistance rates were observed for Trimethoprim/Sulfamethoxazole (84%), Cefalotin (66%), Cefuroxime (50%), Cefixime (50%), and Ceftriaxone (45%).
  • Meropenem (98%), Amikacin (95%), and Nitrofurantoin (91%) showed high susceptibility.
  • ESBL production was detected in 32% of community and 42% of nosocomial isolates.

Conclusions:

  • Significant antimicrobial resistance and ESBL production in pediatric E. coli UTI isolates necessitate local surveillance.
  • Findings highlight the need for region-specific data to guide empirical antibiotic therapy for pediatric UTIs.

Keywords:
Antimicrobial susceptibilityE. coliESBLUrinary Tract Infection

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