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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Updated: May 7, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Liver-specific deceased donor risk indices.

Zifa Wang1, Garrett Hisatake, Libin Yang

  • 1Department of Transplant, California Pacific Medical Center, San Francisco, California, USA; Department of General Surgery, First Affiliated Hospital, Xinxiang Medical University, Weihui, China.

Hepatology Research : the Official Journal of the Japan Society of Hepatology
|September 17, 2013
PubMed
Summary

Procuring surgeons must evaluate specific donor risk factors beyond general indices to optimize liver transplant outcomes. Key factors include liver steatosis, hepatitis status, sodium levels, and anatomical variations for better graft selection.

Keywords:
anti-hepatitis B core positive donorshepatic artery variationshepatitis C virus positive allograftsliver steatosisliver transplantation

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Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

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Last Updated: May 7, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Ex Situ Normothermic Machine Perfusion of Donor Livers
12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Area of Science:

  • Hepatology
  • Transplantation Surgery
  • Organ Procurement

Background:

  • Donor liver quality assessment is crucial for successful liver transplantation.
  • General donor risk indices (age, cause of death, ischemic time) are insufficient alone.
  • Specific donor risk factors significantly impact graft function and patient outcomes.

Purpose of the Study:

  • To review and highlight liver-specific deceased donor risk indices.
  • To provide guidance on evaluating donor livers based on specific risk factors.
  • To improve organ selection protocols in liver transplantation.

Main Methods:

  • Review of literature focusing on liver-specific donor risk factors.
  • Analysis of the impact of liver steatosis, hepatitis status, hypernatremia, and anatomical variations.
  • Discussion of current standards and potential improvements in assessment.

Main Results:

  • Liver steatosis (>40-50% macrosteatosis) is linked to poor graft function; automated analysis is recommended.
  • Anti-hepatitis B core (HBc) positive and HCV positive allografts can be safely used in specific recipient populations.
  • Donor hypernatremia (>150 mEq/L) may indicate primary non-function, though its impact is debated.
  • Hepatic artery variations (~30% incidence) require precise identification during procurement to prevent injury.

Conclusions:

  • Accurate assessment of liver-specific donor risk indices is essential for optimal liver graft selection.
  • Standardized methods for quantifying liver steatosis are needed.
  • Careful consideration of donor hepatitis status and anatomical variations improves transplant success.
  • Further research on donor sodium levels' clinical impact is warranted.