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Updated: May 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation
Raghu Raj1, Christophe Biot, Séverine Carrère-Kremer
1Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India.
Abstract:
A library of quinoline-β-lactam-based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N-1 substituent of the β-lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide.
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