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Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
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Virus budding and the ESCRT pathway.

Jörg Votteler1, Wesley I Sundquist

  • 1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA.

Cell Host & Microbe
|September 17, 2013
PubMed
Summary
This summary is machine-generated.

Enveloped viruses use the cell's ESCRT machinery to bud off from infected cells. This viral budding process offers insights into cellular membrane dynamics and cell division mechanisms.

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Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Enveloped viruses exit host cells via membrane budding.
  • The endosomal sorting complexes required for transport (ESCRT) pathway is crucial for this viral egress.
  • ESCRT machinery also mediates cellular membrane fission events, including cytokinesis.

Purpose of the Study:

  • To review how enveloped viruses hijack the cellular ESCRT pathway for budding.
  • To discuss mechanistic models of ESCRT function in viral budding and cellular processes.
  • To identify key research frontiers in virus-host interactions involving ESCRT.

Main Methods:

  • Literature review of studies on viral budding and ESCRT pathway.
  • Analysis of conserved viral strategies for ESCRT recruitment.
  • Comparison of ESCRT functions in viral egress and cellular membrane dynamics.

Main Results:

  • Viruses mimic cellular ESCRT recruitment signals to exploit this pathway.
  • ESCRT-mediated viral budding shares mechanistic principles with cellular membrane fission.
  • Understanding viral budding provides insights into ESCRT-dependent cellular trafficking and division.

Conclusions:

  • The ESCRT pathway is a central target for enveloped virus egress.
  • Studying viral usurpation of ESCRT illuminates fundamental cell biology.
  • Future research should focus on ESCRT pathway regulation and therapeutic targeting.