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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: May 7, 2026

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

Innate immune cells in asthma.

Julie Deckers¹, Filipe Branco Madeira, Hamida Hammad

¹Laboratory of Immunoregulation and Mucosal Immunology, DMBR-VIB, Zwijnaarde, Belgium; Laboratory of Immunoregulation, Ghent University, Ghent, Belgium; Cytokine Receptor Laboratory, VIB Department of Medical Protein Research, Ghent, Belgium.

Trends in Immunology

|September 17, 2013

Summary

Asthma involves airway inflammation driven by T helper 2 (Th2) responses. This review details how innate immune cells and structural cells interact to orchestrate Th2 immunity in asthma pathogenesis.

Keywords:

Th2 asthma innate cells lung

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Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

Area of Science:

Immunology
Respiratory Medicine
Cell Biology

Background:

Asthma is characterized by T helper 2 (Th2) mediated airway inflammation.
Complex interactions between innate and structural cells are crucial for Th2 responses in the lungs.

Purpose of the Study:

To review the roles of various immune cells in asthma pathogenesis.
To elucidate the interactions between immune and structural cells in orchestrating Th2 immunity.

Main Methods:

Literature review of immune cell interactions in asthma.
Analysis of the roles of dendritic cells, epithelial cells, mast cells, basophils, eosinophils, and group 2 innate lymphoid cells (ILC2s).

Main Results:

Dendritic cells (DCs) are key in allergen sensitization, requiring epithelial signals for activation.
Epithelial cells support activation and survival of mast cells (MCs), basophils, eosinophils, and ILC2s.
Innate cells reciprocally activate DCs, sustaining Th2 immunity.

Conclusions:

Immune cell crosstalk is fundamental to Th2-driven asthma pathogenesis.
Understanding these interactions provides insights into therapeutic targets for asthma.