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Shifting focus in optical image-guided cancer therapy
Stijn Keereweer1, Pieter B A A Van Driel, Dominic J Robinson
1Department of Molecular Imaging, Leiden University Medical Center, Leiden, The Netherlands, s.keereweer@erasmusmc.nl.
Molecular Imaging and Biology
|September 17, 2013
Summary
New fluorescence imaging techniques targeting the follicle-stimulating hormone receptor (FSHR) could improve cancer surgery by better defining tumor margins and addressing tumor heterogeneity, potentially guiding adjuvant therapies.
Area of Science:
- Oncology
- Surgical Oncology
- Biomedical Imaging
Background:
- Intraoperative optical imaging using tumor-specific fluorescence agents aids surgeons in determining adequate tumor resection margins.
- Tumor heterogeneity and variations in tissue optical properties complicate accurate margin assessment.
- Current targeting strategies face limitations in addressing these challenges.
Purpose of the Study:
- To explore novel strategies for improving tumor margin assessment and resection in cancer surgery.
- To investigate the potential of targeting the follicle-stimulating hormone receptor (FSHR) to overcome tumor heterogeneity.
- To discuss methods for objective determination of resection margins and adjuvant therapies.
Main Methods:
- Overview of classic tumor-specific imaging approaches and their limitations.
- Proposal of targeting the follicle-stimulating hormone receptor (FSHR) to circumvent tumor heterogeneity.
- Discussion of objective margin determination and adjuvant photodynamic therapy.
- Description of point optical spectroscopy for tissue analysis.
Main Results:
- Targeting FSHR offers a theoretical solution to tumor heterogeneity in margin assessment.
- Objective margin determination is crucial for resecting invasive tumor strands.
- Point optical spectroscopy can differentiate suspect tissue by analyzing local optical properties.
Conclusions:
- Targeting FSHR presents a promising strategy to enhance tumor-specific imaging and improve surgical resection accuracy.
- Adjuvant photodynamic therapy is a suitable regimen for residual invasive strands.
- Point optical spectroscopy provides a method for scrutinizing tissue at surgical margins.
